SportsafeTM Genetic Testing

WHAT IS APOE?

ApoE is the gene that encodes for apolipoprotein E, a protein that regulates the binding and distribution of cholesterol and triglycerides in the blood throughout your body. This gene has three variations; ApoE2 is thought to be low risk, ApoE3 is neutral and ApoE4 presents the high risk variation.

LEARN & PROTECT

Some variations of ApoE can become less efficient in clearing the build up of cholesterol, commonly referred to as plaque, from your blood after experiencing a concussion or head injury. People with E4 variations should avoid high impact sports, where the risk of head injury can significantly increase.

Ready to take the test and make confident choices?

Prevent Injury for Your Child

APOE e4 has been a risk factor for both traumatic head injury and poor response following a traumatic head injury. Prevention and protection is the best-known epigenetic interaction to reduce these risks that often result in cognitive impairments. Millions of Americans have two copies of the ApoE ε4 variation, categorized as high-risk individuals. Up to 15% of the population have at least one copy of ApoE ε4.

APOE ε4 has been linked with negative outcomes after traumatic brain injury or concussions. —(Freidman et al., Langlois JA, Isoniemi, et al., Johnsons V. et al.).

Of the 200 athletes tested in a cross-sectional study by Tierney et al. in 2010, four carried the APOE4 variant, and three of those four had had a history of concussions. —(Tierney et al.)

KEEP YOUR HEAD IN THE GAME

SportSafeTM Genetic Test is the only full sequence genetic analysis to know your variation on ApoE, designed to help you make informed decisions on which sports and recreational activities to keep your family safe.

MAKE CONFIDENT CHOICES

The damaging effects of brain injury and/or concussion are now widely reported throughout contact sports like football, hockey and soccer, which accounts for up to 3.8 million incidences per year. (CDC) High risk for head injuries:

• Football

• Soccer

• Lacrosse

• Boxing/MMA

• Hockey

• Prior concussion

WHY SHOULD YOU KNOW?

Reasons why people choose to be SportSafeTM Genetic Test:

• Know your variation on APOE

• Help choose the right sports and activities for your children

• Better defend and equip your family during high impact sports

• Better understand your risks of brain trauma from collisions/ concussions

• Learn how some supplements may minimize long term damage after a concussion

PREVENT & PROTECT

APOE e4 has been a risk factor for both traumatic head injury and poor response following a traumatic head injury. Prevention and protection is the best-known epigenetic interaction to reduce these risks that often result in cognitive impairments. Millions of Americans have two copies of the ApoE ε4 variation, categorized as high-risk individuals. Up to 15% of the population have at least one copy of ApoE ε4.

IN SHORT

Some variations of ApoE can become less efficient in clearing the build up of cholesterol, commonly referred to as plaque, from your blood after experiencing a concussion or head injury. People with E4 variations should avoid high impact sports, where the risk of head injury can significantly increase.

WHAT IS APOE?

ApoE is the gene that encodes for apolipoprotein E, a protein that regulates the binding and distribution of cholesterol and triglycerides in the blood throughout your body. This gene has three variations; ApoE2 is thought to be low risk, ApoE3 is neutral and ApoE4 presents the high risk variation.

FROM THE EXPERTS

APOE ε4 has been linked with negative outcomes after traumatic brain injury or concussions. —(Freidman et al., Langlois JA, Isoniemi, et al., Johnsons V. et al.).

Of the 200 athletes tested in a cross-sectional study by Tierney et al. in 2010, four carried the APOE4 variant, and three of those four had had a history of concussions. —(Tierney et al.)

“..the leading cause of death from sports-related injuries is traumatic brain injury.” —Center for Neuro and Spine Inc.

“…Approximately 1.7 million people suffer a traumatic brain injury annually…” —National conference of State Legislature

Based on my experience, there has not been any NFL player I’ve examined that did not have CTE. —Dr. Bennet Omalu

“Sports such as rugby are causing a “silent epidemic” of brain damage and dementia among former players who suffered concussion…” —Head Games

“…several studies have demonstrated worse clinical outcomes in e4 carriers following a traumatic brain injury or concussion.” —(Chronic Traumatic Encephalopathy: A Neurodegenerative Disease Caused by Brain Injury Thor D. Stein, MD, PhD)

“all 4 alleles (rare) 10 x more likely to report prev. concussion”, “Promotor allele only - 8.4 x more likely to report prev concussions” —(Tierney, et al. Clin J Sport Med, 2010)

“…knowing a player’s genetic make-up might help players -- and their parents and coaches and doctors -- make educated decisions that could ultimately help prevent concussions and degenerative diseases.” —Dr. Robert Stern, a professor of neurology at Boston University

TBI patients with APOE4 were more than twice as likely as those without the APOE4 allele to have an unfavorable outcome 6 months after TBI. —(WEIDONG ZHOU, et. al JOURNAL OF NEUROTRAUMA 25:279–290 (April 2008)

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